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Chemical and Biological Process Development

Jon Magnuson

Pacific Northwest National Laboratory
PO Box 999
Richland, WA 99352

Biography

Jon Magnuson is a biochemist with more than 20 years of research experience studying enzymes and metabolic pathways in bacteria and fungi. Dr. Magnuson is currently part of a team utilizing filamentous fungi in the development of processes for converting renewable biomass to fuels, chemicals and enzymes. This research involves the discovery and manipulation of genes encoding the enzymes of biosynthetic pathways or the regulation of those pathways. Complementary to this work is his major interest in fungal genomics. He is involved in the annotation and analysis of many fungal genomes with particular focus on the enzymes involved in the breakdown of plant biomass into sugars. Another area of his research is developing tools to assess and understand the diversity of fungi and other eukaryotic microbes found in different natural environments. This research has culminated in the development of a microarray based on a highly variable region of the ribosomal RNA gene, which is useful for the study of the diverse fungi, diatoms and green algae found in soils, sediments and natural biofilms.

Education and Credentials

  • Ph.D., Biochemistry, University of Minnesota, 1993
  • B.S., Biochemistry, University of Minnesota, 1986

Selected Publications

2009

  • Jovanovic I, JK Magnuson, FR Collart, B Robbertse, WS Adney, ME Himmel, and SE Baker. 2009. "Fungal glycoside hydrolases for saccharification of lignocellulose: outlook for new discoveries fueled by genomics and functional studies." Cellulose 16(4):687-697. 
  • Miracle AL, VL Bailey, SE Baker, AL Bunn, JK Magnuson, and BJM Webb-Robertson. 2009. "Integration of ‘omics technologies for characterization of complex microbial ecosystems - 8119." In Waste Management Symposium 2008, pp. 832-841.  WM Symposia, Tucson, AZ. 

2008

  • Martinez AD, R Berka, B Henrissat, M Saloheimo, M Arvas, SE Baker, J Chapman, O Chertkov, PM Coutinho, D Cullen, EG Danchin, IV Grigoriev, P Harris, M? Jackson, CP kubicek, CF Han, I Ho, LF Larrando, A Lopez de Leon, JK Magnuson, S Merino, M Misra, B Nelson, N Putnam, B Robbertse, A Salamov, M Schmoll, A? Terry, N Thayer, A Westerholm-Parvinen, CL Schoch, J? Yao, R Barbote, MA Nelson, CJ Detter, D Bruce, C Kuske, G Xie, PM Richardson, DS Rokhsar, S Lucas, EM Rubin, N Dunn-Coleman, M? Ward, and T Brettin. 2008. "Genome Sequencing and Analysis of the Biomass-Degrading Fungus Trichoderma reesei (syn. Hypocrea jecorina) ." Nature Biotechnology 26(5):553-560. 

2007

  • Cuomo CA, U Guldener, JR Xu, F Trail, BG Turgeon, A Di Pietro, JD Walton, LJ Ma, SE Baker, M Rep, G Adam, J Antoniw, T Baldwin, S Calvo, YL Chang, D DeCaprio, LR Gale, S Gnerre, RS Goswami, K Hammond-Kossack, LJ Harris, K Hilburn, JC Kennell, S Kroken, JK Magnuson, G Mannhaupt, E Mauceli, HW Mewes, R Mitterbauer, G Muehlbauer, M Munsterkotter, D Nelson, K O'Donnell, T Ouellet, W Qi, H Quesneville, MI Roncero, KY Seong, IV Tetko, M Urban, C Waalwijk, TJ Ward, J Yao, BW Birren, and HC Kistler. 2007. "The Fusarium Graminearum Genome Reveals a Link Between Localized Polymorphism and Pathogen Specialization." Science 317(5843):1400-1402.  doi:10.1126/science.1143708

2006

  • Elliott DC, JK Magnuson, and CF Wend. 2006. 3.1.1.2 Feed Processing and Handling DL2 Final Report PNNL-16079, Pacific Northwest National Laboratory, Richland, WA. 
  • Lei C, Y Shin, JK Magnuson, GE Fryxell, LL Lasure, DC Elliott, J Liu, and EJ Ackerman. 2006. "Characterization of Functionalized Nanoporous Supports for Protein Confinement ." Nanotechnology 17(22):5531-5538.  doi:10.1088/0957-4484/17/22/001

2004

  • Magnuson JK, and LL Lasure. 2004. "Organic Acid Production by Filamentous Fungi." Chapter 12 in ADVANCES IN FUNGAL BIOTECHNOLOGY FOR INDUSTRY, AGRICULTURE, AND MEDICINE, ed. Jan S. Tkacz and Lene Lange, pp. 307-340.  Kluwer Academic/Plenum Publishers, New York, NY. 
  • Dai Z, X Mao, JK Magnuson, and LL Lasure. 2004. "Identification of Genes Associated with Morphology in Aspergillus Niger by Using Suppression Subtractive Hybridization ." Applied and Environmental Microbiology 70(4):2474-2485. 
  • Syn CK, JK Magnuson, MT Kingsley, and S Swarup. 2004. "Characterization of Pseudomonas putida Genes Responsive to Nutrient Limitation." Microbiology 150:1661-69 pt.6. 

2003

2002

  • de Henestrosa AR, J Cune, I Erill, JK Magnuson, and J Barbe. 2002. "A Green Nonsulfur Bacterium, Dehalococcoides ethenogenes, with the LexA-binding sequence found in Gram-positive organisms." Journal of Bacteriology 184(21):6073-6080. 

2000

  • Magnuson JK, MF Romine, DR Burris, and MT Kingsley. 2000. "Trichloroethene Reductive Dehalogenase from Dehalococcoides ethenogenes: Sequence of tceA and Substrate Range Characterization." Applied and Environmental Microbiology 66:5141-5147. 

Chemical and Biological Process Development

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